The first study is a research trial conducted at a local hospital, Duke University Hospital, where neurosurgeons are using recombinant, nonpathogenic polio-rhinovirus to treat grade IV malignant glioma, or glioblastoma, a severe and aggressive brain tumor with a typically-dismal prognosis. However, patients with recurrent glioblastoma enrolled in the clinical trial at the Duke Cancer Institute are seeing a three-year survival rate of 21% in phase 1 of the trial compared to just 4% for the patients undergoing the previously-available standard treatment at Duke. Read more about the trial here (Links to an external site.). The poliovirus therapy obtained “breakthrough therapy designation” in 2016 from the U.S. Food and Drug Administration.
Access the following quantitative article regarding the trial described above: (can access via C.G. O’Kelly Library (Links to an external site.))
Desjardins, A., Gromeier, M., Herndon, J. E., Beaubier, N., Bolognesi, D. P., Friedman, H. S., & Bigner, D. D. et al. (2018). Recurrent glioblastoma treated with recombinant poliovirus. The New England Journal of Medicine, 379(2). doi:10.1056/NEJMoa1716435
a. What type of quantitative research is this? Justify your response. What are the strengths and limitations of this type of research?
b. Discuss the study’s sample size. Was this an appropriate sample? Why might the sample size not be larger?
c. Imagine you are the RN caring for a patient enrolled in this trial. Describe three nursing interventions or considerations pertaining to the care of this patient.
d. What are the implications of this study in terms of the future of cancer treatment? Find and describe another example of oncolytic virus therapy.
2. Access the following qualitative article regarding the lived experiences of patients with glioblastomas:(can access via C.G. O’Kelly Library (Links to an external site.))
Sterckx, W., Coolbrandt, A., Clement, P., Borgenon, S., Decruyenaere, M., De Vleeschouwer, S., & Dierckx de Casterlé, B. (2015). Living with a high-grade glioma: A qualitative study of patients’ experiences and care needs. European Journal of Oncology Nursing, 279(2). doi:10.1016/j.ejon.2015.01.003
a. Describe the strengths and limitations of qualitative research.
b. Complete the following table:
(briefly describe) and how this affected study techniques
(also, describe strengths and weakness)
c. Assess the generalizability of this study. Describe three nursing interventions that a BSN-prepared nurse might implement for the care of patients with this same disease process at their own institution based on the results of this study.
d. List three things that a BSN-prepared nurse might incorporate the results of this study in the teaching or education they provide to the family or caretakers of a patient with a high-grade glioma.
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