Cell & Tissue Operate/Dysfunction
Atrophy: lower in dimension of cells.
Hypertrophy: improve in cell dimension.
Hyperplasia: improve in variety of cells.
Metaplasia: mature cell sort is changed by a distinct mature cell sort.
Dysplasia: cells range in dimension & form inside a tissue.
Anaplasia: undifferentiated cells with variable nuclear & cell construction.
Neoplasm: tumor.
Cell Harm
Ischemia: oxygen deficit as a result of respiratory or circulatory issues.
Hypoxia: diminished oxygen in tissue.
Oxygen Deficit: decreased power manufacturing, lack of Na pump ↑ intracellular Na.
Temperature: inactivation of some enzymes, damages organelles, protein coagulation, disruption of cell membrane.
Micro-organisms
Irregular Metabolites: attributable to genetic issues or altered metabolism.
Dietary Deficits
Cell Dying
Apoptosis:programmed cell dying managed by genetics.
Necrosis:lysis of a cell, cell parts leak into blood.
Liquification:useless cells liquefy as a result of launch of enzymes.
Coagulation:cell proteins are altered or denatured inflicting coagulation.
Caseous:type of coagulation necrosis, thick, yellowish, tacky.
Fats: fatty tissue is damaged down into fatty acids.
Tissue Harm from Chemical substances
Exogenous: from surroundings.
Endogenous: from contained in the physique,
Tissue Harm from Bodily Brokers
Hypothermia: vasoconstriction, ↑ blood viscosity, hypovolemic shock ↓ blood strain.
Hyperthermia: causes normal vasodilatation, lower in circulating blood quantity.
Radiation: primarily impacts actively dividing cells
Organic Brokers
Bugs/Animals: direct injection of toxin, transmission of infectious agent, allergic response to insect proteins.
Meals Poisoning
Regular Defenses of the Physique
1st Line Protection
Bodily Limitations: unbroken pores and skin, mucous membranes, nasal hair, clots.
Fluids: might include enzymes or chemical compounds:saliva, tears, gastric, sweat.
2nd Line Protection-non-specific
Phagocytosis:neutrophils & macrophages engulf cells, particles, overseas mat.
Irritation: automated response to cell damage.
third Line Protection-specific protection produced by
Antibodies
Cell Mediated Immunity
Mobile Defenses
Mast Cells: positioned in tissue & launch histamine & bradykinin.
Macrophages: monocytes that enter tissue & act as phagocytes.
Interferons: small proteins made by lymphocytes to stop virus replication.
White Blood Cells
Granulocytes
Neutrophils: work by phagocytosis.
Basophils: launch histamine resulting in irritation.
Eosinophils:fight the consequences of histamine.
Agranulocytes
Monocytes:can enter tissue to turn into macrophages which operate as phagocyte.
Lymphocytes: B & T
Acute Irritation
Vascular Response: vasodilatation & elevated capillary permeability.
Mobile Response: migration of inflammatory cells by way of chemotaxis to damage website to destroy ineffective organism, take away broken cells, launched irritation mediators.
Exudate
Serous: watery, largely fluids, some proteins and WBC’s.
Fibrinous: thick, sticky, excessive fibrin content material.
Purulent: thick, yellow-green, accommodates leukocytes, cell particles & microorganisms.
Abscess: Pocket of purulent exudates or pus in a stable tissue.
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Operate/Dysfunction of Cells and Tissues
Cell atrophy refers to a discount in cell dimension.
Hypertrophy is outlined as a rise in cell dimension.
Hyperplasia is outlined as an increase within the variety of cells.
Metaplasia happens when one mature cell sort is changed by one other mature cell sort.
Dysplasia happens when cells inside a tissue range in dimension and kind.
Anaplasia is characterised by undifferentiated cells with various nuclear and cell construction.
Tumor: a neoplasm.
Mobile Harm
Ischemia is an absence of oxygen attributable to respiratory or circulatory points.
Hypoxia: diminished oxygen in tissue.
Oxygen Deficit: decreased power manufacturing, lack of Na pump ↑ intracellular Na.
Temperature: inactivation of some enzymes, damages organelles, protein coagulation, disruption of cell membrane.
Micro-organisms
Irregular Metabolites: attributable to genetic issues or altered metabolism.
Dietary Deficits
Cell Dying
Apoptosis:programmed cell dying managed by genetics.
Necrosis:lysis of a cell, cell parts leak into blood.
Liquification:useless cells liquefy as a result of